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Senior Scientist in Mechanistic Biology
8/16/2010
Cambridge, MA
The successful candidate will work with the Biology group and lead efforts designed to further our understanding of pepducin mechanisms of action. The candidate will be responsible for designing, developing and applying in vitro assays to characterize the pharmacological and biophysical properties of lipidated peptides. He/she will lead investigations exploring the interface between lipidated peptides and cellular membranes and integral membrane proteins. The successful candidate, in addition to other research endeavors, will direct a research program investigating the insertion and distribution of lipidated peptides in cellular membranes. As such, he/she should possess strong working knowledge of peptide, lipid and membrane biology. He/she should be an effective, self-motivated, and creative scientist capable of independently executing, analyzing, and troubleshooting experiments. The position requires excellent oral and written communication skills as well as strong organizational and critical thinking skills. The successful candidate should function well in a group setting and be an active contributor to both the biology and chemistry groups.
The position requires a strong applied background in biochemical and biophysical techniques typically associated with a Ph.D. in biochemistry, biophysics or a similar filed. Experienced MS level scientists will also be considered. Experience working with cellular membranes and membrane proteins is essential. The ideal candidate will also have a strong understanding of lipid biochemistry and be able to apply this knowledge in the development of lipidated peptide therapeutics. Experience with molecular modeling and molecular dynamics (MD) simulations is preferred. Experience with advance biochemical and biophysical techniques including CD, FTIR, ITC, DSC, HPLC and NMR is desirable.
If interested please contact:
Christian Hansen
JTT Group
919-460-1990 office
617-694-1969 mobile
Christian@jttgroup.com
If you're interested in this position, please send your resume/CV to Info@JTTGroup.com, and a representative will contact you. Your information will be kept confidential.
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